Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway.

@article{Janody2001TwoDD,
  title={Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway.},
  author={Florence Janody and Rachel Sturny and V{\'e}ronique Schaeffer and Yannick Azou and Nathalie Dostatni},
  journal={Development},
  year={2001},
  volume={128 12},
  pages={2281-90}
}
The transcriptional activity of the Bicoid morphogen is directly downregulated by the Torso signal transduction cascade at the anterior pole of the Drosophila embryo. This regulation does not involve the homeodomain or direct phosphorylation of Bicoid. We analyse the transcriptional regulation of Bicoid in response to the Torso pathway, using Bicoid variants and fusion proteins between the Bicoid domains and the Gal4 DNA-binding domain. We show that Bicoid possesses three autonomous activation… CONTINUE READING
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