Two distinct domains in pro-region of Nodal-related 3 are essential for BMP inhibition.

@article{Haramoto2006TwoDD,
  title={Two distinct domains in pro-region of Nodal-related 3 are essential for BMP inhibition.},
  author={Yoshikazu Haramoto and Shuji Takahashi and Makoto Asashima},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={346 2},
  pages={
          470-8
        }
}
The transforming growth factor-beta (TGF-beta) superfamily member, Xenopus nodal-related 3 (Xnr3), induces neural tissues through inhibition of bone morphogenetic proteins (BMPs). We recently identified an inhibitory mechanism in which the pro-region of Xenopus tropicalis nodal-related 3 (Xtnr3) physically interacts with BMP ligands. Here, we show that disulfide-linked heterodimerization does not contribute to BMP inhibition by Xtnr3 and that the Xtnr3 mature region, overexpression of which can… CONTINUE READING
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