Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

@article{Shyu1991TwoDD,
  title={Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.},
  author={A B Shyu and Joel G. Belasco and Michael E. Greenberg},
  journal={Genes & development},
  year={1991},
  volume={5 2},
  pages={
          221-31
        }
}
  • A B Shyu, Joel G. Belasco, Michael E. Greenberg
  • Published in Genes & development 1991
  • Biology, Medicine
  • The mechanisms by which c-fos mRNA is targeted for decay have been examined. Rapid removal of the poly(A) tail occurs before the transcribed portion of the c-fos message is degraded. Identification of the determinants that mediate c-fos message deadenylation reveals that they coincide directly with previously characterized determinants of c-fos mRNA instability, one in the protein-coding region and the other an AU-rich element (ARE) in the 3'-untranslated region. Insertion of either of these c… CONTINUE READING

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