Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells.

@article{McMillian1993TwoDC,
  title={Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells.},
  author={M. McMillian and Stephen P. Soltoff and Lewis C. Cantley and R G Rudel and Barbara R. Talamo},
  journal={British journal of pharmacology},
  year={1993},
  volume={108 2},
  pages={453-61}
}
1. Increasing concentrations of ATP (0.5 microM-300 microM) produced a biphasic increase in intracellular calcium concentration [Ca]i in rat parotid acinar cells, reflecting two distinct Cai responses to extracellular ATP. 2. In the absence of Mg2+ (with 3 mM CaCl2 in the buffer solution), the more sensitive response was maximal at 3-5 microM and was not further increased by 30 microM ATP. This response to ATP was not well maintained and was blocked by ADP (0.5 mM). A second, much larger… CONTINUE READING

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