Two distinct central serotonin receptors with different physiological functions.

@article{Peroutka1981TwoDC,
  title={Two distinct central serotonin receptors with different physiological functions.},
  author={Stephen J. Peroutka and Robert M. Lebovitz and Solomon H Snyder},
  journal={Science},
  year={1981},
  volume={212 4496},
  pages={827-9}
}
Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to… CONTINUE READING

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