• Biology, Medicine
  • Published in
    The Journal of biological…
    1991

Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.

@article{Corjay1991TwoDB,
  title={Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.},
  author={Martha H. Corjay and David Dobrzanski and James M. Way and Jean Viallet and Hagit Shapira and Peter Worland and Edward A. Sausville and James F. Battey},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 28},
  pages={
          18771-9
        }
}
Bombesin-like peptides have been implicated as autocrine growth factors influencing the pathogenesis and progression of some human lung carcinoma cells. To determine the pharmacologic and structural properties of the bombesin receptors expressed in human lung carcinoma cells, cDNA clones encoding a human gastrin-releasing peptide receptor (GRP-R) and a pharmacologically distinct neuromedin-B preferring bombesin-receptor (NMB-R) were isolated from a human small cell lung carcinoma cell line (NCI… CONTINUE READING

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References

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