Two distinct arsenite-resistant variants of Leishmania amazonensis take different routes to achieve resistance as revealed by comparative transcriptomics.

@article{Lin2008TwoDA,
  title={Two distinct arsenite-resistant variants of Leishmania amazonensis take different routes to achieve resistance as revealed by comparative transcriptomics.},
  author={Yi-Chun Lin and J Hsu and Jui-Hsu Shu and Yi - ching Ming Chi and S Chiang and Sho Tone Lee},
  journal={Molecular and biochemical parasitology},
  year={2008},
  volume={162 1},
  pages={16-31}
}
Genome-wide search for the genes involved in arsenite resistance in two distinct variants A and A' of Leishmania amazonensis revealed that the two variants used two different mechanisms to achieve resistance, even though these two variants were derived from the same clone and selected against arsenite under the same conditions. In variant A, the variant with DNA amplification, the biochemical pathways for detoxification of oxidative stress, the energy generation system to support the… CONTINUE READING

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