Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein.

@article{Nevels2000TwoDA,
  title={Two distinct activities contribute to the oncogenic potential of the adenovirus type 5 E4orf6 protein.},
  author={Michael Nevels and S Rubenwolf and Thilo Spruss and H. -R. Wolf and Thomas Dobner},
  journal={Journal of virology},
  year={2000},
  volume={74 11},
  pages={5168-81}
}
Previous studies have shown that the adenovirus type 5 (Ad5) E4orf6 gene product displays features of a viral oncoprotein. It initiates focal transformation of primary rat cells in cooperation with Ad5 E1 genes and confers multiple additional transformed properties on E1-expressing cells, including profound morphological alterations and dramatically accelerated tumor growth in nude mice. It has been reported that E4orf6 binds to p53 and, in the presence of the Ad5 E1B-55kDa protein, antagonizes… CONTINUE READING