Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by initiator DnaA-ATP.

@article{McGarry2004TwoDB,
  title={Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by initiator DnaA-ATP.},
  author={Kevin C McGarry and Valorie T Ryan and Julia E. Grimwade and Alan C. Leonard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 9},
  pages={2811-6}
}
Initiation of DNA replication in eukaryotes, archea, and eubacteria requires interaction of structurally conserved ATP-binding initiator proteins and origin DNA to mediate assembly of replisomes. However, the specific requirement for ATP in the early steps of initiation remains unclear. This is true even for the well studied Escherichia coli replication origin, oriC, where the ATP form of initiator DnaA is necessary and sufficient for initial DNA strand separation, but the five DnaA-binding… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
59 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Protein Expression Purif

  • Z. Li, E. Crooke
  • 1999

Molecular Cloning: A Laboratory Manual (Cold

  • J. Sambrook, E. F. Fritsch, T. Maniatis
  • 1989

Similar Papers

Loading similar papers…