Two-dimensional protein electrophoresis: From molecular pathway discovery to biomarker discovery in neurological disorders

@article{Choe2006TwodimensionalPE,
  title={Two-dimensional protein electrophoresis: From molecular pathway discovery to biomarker discovery in neurological disorders},
  author={Leila H. Choe and Brenda G. Werner and Kelvin H. Lee},
  journal={NeuroRX},
  year={2006},
  volume={3},
  pages={327-335}
}
Two-dimensional protein electrophoresis (2-DE) has undergone many technical improvements in the past 30 years, resulting in an analytical method that is unparalleled in the resolution of complex protein mixtures and capable of quantifying changes in protein expression from a wide variety of tissues and samples. The technique has been applied in many studies of neurologic disease to identify changes in spot patterns that correlate with disease. The true power of the technique emerges when it is… CONTINUE READING
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