Two-dimensional liquid chromatography/tandem mass spectrometry analysis of Gradiflow fractionated native human plasma.

@article{Wasinger2005TwodimensionalLC,
  title={Two-dimensional liquid chromatography/tandem mass spectrometry analysis of Gradiflow fractionated native human plasma.},
  author={Valerie C Wasinger and Vicki L Locke and Mark J. Raftery and Mark Larance and Deborah L Rothemund and Audrey Liew and Irene M Bate and Michael Guilhaus},
  journal={Proteomics},
  year={2005},
  volume={5 13},
  pages={3397-401}
}
One of the major challenges facing protein analysis is the dynamic range of protein expression within massively complex samples (Corthals, G. L. et al.., Electrophoresis 2000, 21, 1104-1115). In plasma this difference is as great as ten orders of magnitude, and this is currently beyond the range of detection achievable by any of the analytical techniques. Plasma has the additional challenge of having a few highly abundant proteins, such as albumin, which mask the detection of lower abundance… CONTINUE READING

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