Two-dimensional isobutyl acetate production pathways to improve carbon yield

@inproceedings{Tashiro2015TwodimensionalIA,
  title={Two-dimensional isobutyl acetate production pathways to improve carbon yield},
  author={Yohei Tashiro and Shuchi H. Desai and Shota Atsumi},
  booktitle={Nature communications},
  year={2015}
}
For an economically competitive biological process, achieving high carbon yield of a target chemical is crucial. In biochemical production, pyruvate and acetyl-CoA are primary building blocks. When sugar is used as the sole biosynthetic substrate, acetyl-CoA is commonly generated by pyruvate decarboxylation. However, pyruvate decarboxylation during acetyl-CoA formation limits the theoretical maximum carbon yield (TMCY) by releasing carbon, and in some cases also leads to redox imbalance. To… CONTINUE READING