Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Aβ40

@article{Kim2008TwodimensionalIS,
  title={Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from A$\beta$40},
  author={Y. S. Kim and L. Liu and P. Axelsen and R. Hochstrasser},
  journal={Proceedings of the National Academy of Sciences},
  year={2008},
  volume={105},
  pages={7720 - 7725}
}
The 2D IR spectra of the amide-I vibrations of amyloid fibrils from Aβ40 were obtained. The matured fibrils formed from strands having isotopic substitution by 13C18O at Gly-38, Gly-33, Gly-29, or Ala-21 show vibrational exciton spectra having reduced dimensionality. Indeed, linear chain excitons of amide units are seen, for which the interamide vibrational coupling is measured in fibrils grown from 50% and 5% mixtures of labeled and unlabeled strands. The data prove that the 1D excitons are… Expand
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