Two-dimensional gel electrophoresis of human brain proteins. III. Genetic and non-genetic variations in 145 brains.

@article{Comings1982TwodimensionalGE,
  title={Two-dimensional gel electrophoresis of human brain proteins. III. Genetic and non-genetic variations in 145 brains.},
  author={David E. Comings},
  journal={Clinical chemistry},
  year={1982},
  volume={28 4 Pt 2},
  pages={
          798-804
        }
}
To determine the frequency of genetic mutations, polymorphisms, and non-genetic variation in the major human brain proteins, I examined, by equilibrium two-dimensional gel electrophoresis, 145 brains from patients dying of a wide variety of psychiatric, neurological, and non-neurological disorders. Of 176 polypeptides screened, there was one polymorphism of glial fibrillary acidic protein (GFAP-Duarte). Chi square analysis indicated it was non-randomly distributed among different diseases. A… CONTINUE READING

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