Two-dimensional contrast echocardiography. I. In vitro development and quantitative analysis of echo contrast agents.

@article{Feinstein1984TwodimensionalCE,
  title={Two-dimensional contrast echocardiography. I. In vitro development and quantitative analysis of echo contrast agents.},
  author={Steven B. Feinstein and Folkert J. ten Cate and Werner Zwehl and Kenneth Ong and Gerald Maurer and Chuwa Tei and Pravin M. Shah and S. Meerbaum and Elliot Corday},
  journal={Journal of the American College of Cardiology},
  year={1984},
  volume={3 1},
  pages={14-20}
}
To facilitate the passage of echo contrast agents through the microcirculation and the echocardiographic study of myocardial perfusion, ultrasonic energy (sonication) was employed to produce contrast agents consisting of relatively uniform, stable and small (less than 10 mu diameter) gaseous microbubbles suspended in liquid solutions. The size and persistence of the microbubbles was verified by light microscopy and an in vitro system were employed for comparative assessment of peak echo… CONTINUE READING
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