• Corpus ID: 7438813

Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.

  title={Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.},
  author={H. J. Segall and Jerry L. Dallas and William F. Haddon},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={12 1},
The in vitro mouse hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid senecionine was studied for additional metabolites. Using previously developed HPLC systems plus a preparative system, two additional dihydropyrrolizine metabolites have been identified from the microsomal enzyme system of mice. The metabolites 1-hydroxymethyl-7-methoxy-6,7-dihydro-5H-pyrrolizine (methoxydehydroretronecine) and 1-formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (hydroxydanaidal) have not been… 
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