• Corpus ID: 7438813

Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.

@article{Segall1984TwoDA,
  title={Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.},
  author={H. J. Segall and Jerry L. Dallas and William F. Haddon},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1984},
  volume={12 1},
  pages={
          68-71
        }
}
The in vitro mouse hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid senecionine was studied for additional metabolites. Using previously developed HPLC systems plus a preparative system, two additional dihydropyrrolizine metabolites have been identified from the microsomal enzyme system of mice. The metabolites 1-hydroxymethyl-7-methoxy-6,7-dihydro-5H-pyrrolizine (methoxydehydroretronecine) and 1-formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (hydroxydanaidal) have not been… 
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12 Citations

12 Citations

Citation Type

Citation Type

trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine.
TLDR
A novel metabolite, trans-4-hydroxy-2-hexenal, has been isolated from the macrocyclic pyrrolizidine alkaloid senecionine in an in vitro hepatic microsomal system and appears to be identical to that previously attributed to reactive pyrroles.
THE IDENTIFICATION, METABOLISM AND TOXICITY ASSOCIATED WITH THE MACROCYCLIC PYRROLIZIDINE ALKALOIDS
Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine.
TLDR
In general, in addition to the new metabolites that could make humans more susceptible to lasiocarpine-induced toxicity, the overall metabolite fingerprint detected with the human liver microsomes differed from that of all other species, yielding high levels of GSH-reactive metabolites.
Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography.
Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.
TLDR
Results from the study demonstrate that the relative contributions of the three major pathways of pyrrolizidine alkaloid metabolism can be assessed using a single analytical instrument and minimal sample preparation.
Biological reactive intermediates of pyrrolizidine alkaloids.
TLDR
There is increasing evidence that the PAs are excreted in toxic form in the milk of cows and goats consuming PA containing plants such as tansy ragwort (Senecio jacobaea).
Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation.
  • P. Fu
  • Chemistry, Biology
    Chemical research in toxicology
  • 2017
TLDR
The present perspective reports the current progress on these new findings and proposes future research needed for obtaining a greater understanding of the role of this activation pathway and validating the use of this set of PA-derived DNA adducts as a biological biomarker of PA -induced liver tumor initiation.
Chapter 4 Metabolic Transformations of Alkaloids
Recent Chromatographic Methods to Isolate Pyrrolizidime Alkaloids
Abstract The application of recent chromatographic techniques to isolate various pyrrolizidine alkaloids are evaluated. Alkaloids which have been successfully separated include monoesters, diesters,…
Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice.
  • J. Deyo, N. Kerkvliet
  • Biology, Medicine
    Fundamental and applied toxicology : official journal of the Society of Toxicology
  • 1990
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