Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.
@article{Segall1984TwoDA, title={Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro.}, author={H. J. Segall and Jerry L. Dallas and William F. Haddon}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={1984}, volume={12 1}, pages={ 68-71 } }
The in vitro mouse hepatic microsomal metabolism of the macrocyclic pyrrolizidine alkaloid senecionine was studied for additional metabolites. Using previously developed HPLC systems plus a preparative system, two additional dihydropyrrolizine metabolites have been identified from the microsomal enzyme system of mice. The metabolites 1-hydroxymethyl-7-methoxy-6,7-dihydro-5H-pyrrolizine (methoxydehydroretronecine) and 1-formyl-7-hydroxy-6,7-dihydro-5H-pyrrolizine (hydroxydanaidal) have not been…
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trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine.
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A novel metabolite, trans-4-hydroxy-2-hexenal, has been isolated from the macrocyclic pyrrolizidine alkaloid senecionine in an in vitro hepatic microsomal system and appears to be identical to that previously attributed to reactive pyrroles.
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Abstract The application of recent chromatographic techniques to isolate various pyrrolizidine alkaloids are evaluated. Alkaloids which have been successfully separated include monoesters, diesters,…
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