Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope


BACKGROUND Selective protein import into the cell nucleus occurs in two steps: binding to the nuclear envelope, followed by energy-dependent transit through the nuclear pore complex. A 60 kD protein, importin, is essential for the first nuclear import step, and the small G protein Ran/TC4 is essential for the second. We have previously purified the 60kD… (More)
DOI: 10.1016/S0960-9822(95)00079-0


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