Two different modes of transcription repression of the Escherichia coli acetate operon by IclR.

@article{Yamamoto2003TwoDM,
  title={Two different modes of transcription repression of the Escherichia coli acetate operon by IclR.},
  author={Kaneyoshi Yamamoto and Akira Ishihama},
  journal={Molecular microbiology},
  year={2003},
  volume={47 1},
  pages={183-94}
}
IclR is a repressor for the Escherichia coli aceBAK operon, which encodes isocitrate lyase (aceB), malate synthase (aceA) and isocitrate dehydroge-nase kinase/phosphorylase (aceK) in the glyoxylate bypass. IclR also represses the expression of iclR in an autogenous manner. DNase I footprinting and in vitro transcription assays indicated that IclR binds to an IclR box (-21 to +14), which overlaps the iclR promoter and thus competes with the RNA polymerase for DNA binding, leading to… CONTINUE READING

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