Two different modes of action of pentobarbital at glycine receptor channels.

@article{Mohammadi2004TwoDM,
  title={Two different modes of action of pentobarbital at glycine receptor channels.},
  author={Bahram Mohammadi and Klaus Krampfl and Caner Cetinkaya and Heiner Wolfes and Johannes Bufler},
  journal={European journal of pharmacology},
  year={2004},
  volume={489 3},
  pages={151-6}
}
Glycine receptor channels are pentameric ligand-gated ion channels which respond to the binding of inhibitory transmitters by opening of a chloride-selective central pore. Pentobarbital is widely used as an anticonvulsive, hypnotic and anaesthetic drug. In the present study, the interaction between pentobarbital and glycine receptor channels was studied on outside-out patches of human embryonic kidney (HEK) 293 cells expressing alpha(1)beta glycine receptor channels. Currents elicited by 0.03… CONTINUE READING