Two different forms of p53 localized differently within cells of urogenital tumours.

@article{Benninghoff1999TwoDF,
  title={Two different forms of p53 localized differently within cells of urogenital tumours.},
  author={J Benninghoff and Sabine Kartarius and Z Teleb and H. Selter and Gerhard Unteregger and T. B. H. Zwergel and Bernd Wullich and Mathias Montenarh},
  journal={Cancer letters},
  year={1999},
  volume={144 1},
  pages={55-64}
}
We analyzed the subcellular localization of p53 in prostate and bladder carcinoma cells. Using laser scanning microscopy and PAb1620, a monoclonal antibody recognizing the wildtype conformation of p53, and another monoclonal antibody directed against the mutant conformation of the protein (PAb240), we found two different subsets of p53 within the same cell. The wildtype subgroup was found in the nucleolus, whereas the mutant protein was confined to the nucleus. The results obtained by… CONTINUE READING