Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.

@article{Winqvist1993TwoDC,
  title={Two different cytochrome P450 enzymes are the adrenal antigens in autoimmune polyendocrine syndrome type I and Addison's disease.},
  author={Ola Winqvist and Jan Gustafsson and Fredrik Rorsman and F. Anders Karlsson and Olle K{\"a}mpe},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 5},
  pages={2377-85}
}
Autoimmune polyendocrine syndrome type I (APS I) and idiopathic Addison's disease are both disorders with adrenal insufficiency but with differences in genetic background, clinical presentation, and extent of extraadrenal manifestations. In this study the major adrenal autoantigen identified with sera from patients with APS I was characterized by analyses using indirect immunofluorescence, Western blots of adrenal subcellular fractions and of recombinant proteins, immunoprecipitations of [35S… CONTINUE READING
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