Two different IFN-γ nonresponsive variants derived from the B-cell lymphoma 70Z/3


The kappa immunoglobulin (Igk) light chain locus is transcriptionally silent in the mouse B-cell lymphoma 70Z/3. However, exposure to lipopolysaccharide (LPS) or interferon-γ (IFN) causes a marked increase in Igk transcription. By immunoselection, we isolated two variants that are nonresponsive to IFN. One variant, AT7.2, has retained its response to LPS… (More)
DOI: 10.1007/BF00167080


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