Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.

Abstract

Obesity in humans and in rodents is usually associated with high circulating leptin levels and leptin resistance. To examine the molecular basis for leptin resistance, we determined the ability of leptin to induce hypothalamic STAT3 (signal transducer and activator of transcription) signaling in C57BL/6J mice fed either low-fat or high-fat diets. In mice… (More)

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@article{ElHaschimi2000TwoDC, title={Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity.}, author={Karim El-Haschimi and Dominique D. Pierroz and Susan Hileman and Christian Bj\orbaek and Jacoba Flier}, journal={The Journal of clinical investigation}, year={2000}, volume={105 12}, pages={1827-32} }