Two days of antithymocyte globulin are associated with a reduced incidence of acute and chronic graft-versus-host disease in reduced-intensity conditioning transplantation for hematologic diseases.

@article{Crocchiolo2013TwoDO,
  title={Two days of antithymocyte globulin are associated with a reduced incidence of acute and chronic graft-versus-host disease in reduced-intensity conditioning transplantation for hematologic diseases.},
  author={Roberto Crocchiolo and Benjamin Esterni and Luca Castagna and Sabine F{\"u}rst and J El-cheikh and Raynier Devillier and Angela M Granata and Claire Oudin and Boris Calmels and Christian Chabannon and R{\'e}da Bouabdallah and Norbert Vey and Didier Blaise},
  journal={Cancer},
  year={2013},
  volume={119 5},
  pages={986-92}
}
BACKGROUND The optimal combination of fludarabine, busulfan, and antithymocyte globulin (ATG) for reduced-intensity conditioning (RIC) transplantation has not been established. ATG plays a pivotal role in the prevention of graft-versus-host disease (GvHD), but it is associated with a higher relapse rate and an elevated incidence of infections when high doses are used. METHODS The authors retrospectively compared 2 different doses of ATG combined with fludarabine and busulfan in 229 adult… CONTINUE READING
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