Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo

@article{Benenati2009TwoCP,
  title={Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo},
  author={Gaspare Benenati and S. Penkov and T. M{\"u}ller-Reichert and E. Entchev and T. Kurzchalia},
  journal={Mechanisms of Development},
  year={2009},
  volume={126},
  pages={382-393}
}
  • Gaspare Benenati, S. Penkov, +2 authors T. Kurzchalia
  • Published 2009
  • Biology, Medicine
  • Mechanisms of Development
  • The role of lipids in the process of embryonic development of Caenorhabditis elegans is still poorly understood. Cytochrome P450s, a class of lipid-modifying enzymes, are good candidates to be involved in the production or degradation of lipids essential for development. We investigated two highly similar cytochrome P450s in C. elegans, cyp-31A2 and cyp-31A3, that are homologs of the gene responsible for Bietti crystalline corneoretinal dystrophy in humans. Depletion of both cytochromes either… CONTINUE READING
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