Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita

@article{FraireZamora2017TwoCM,
  title={Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita},
  author={Juan J. Fraire-Zamora and Johannes Jaeger and J{\'e}r{\^o}me Solon},
  journal={eLife},
  year={2017},
  volume={7}
}
Evolution of morphogenesis is generally associated with changes in genetic regulation. Here we report evidence indicating that dorsal closure, a conserved morphogenetic process in dipterans, evolved as the consequence of rearrangements in epithelial organization rather than signaling regulation. In Drosophila melanogaster, dorsal closure consists of a two-tissue system where the contraction of extraembryonic amnioserosa and a JNK/Dpp-dependent epidermal actomyosin cable result in microtubule… 

How two extraembryonic epithelia became one: serosa and amnion features and functions of Drosophila's amnioserosa

It is concluded that the amnioserosa combines cells, genetic pathway components and functions that were previously associated either with serosa development or amnion development, raising the question of whether merging tissue-specific gene networks is a common evolutionary process.

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