Two conformational forms of target-bound iC3b that distinctively bind complement receptors 1 and 2 and two specific monoclonal antibodies

@inproceedings{Nilsson2011TwoCF,
  title={Two conformational forms of target-bound iC3b that distinctively bind complement receptors 1 and 2 and two specific monoclonal antibodies},
  author={Ulf R. Nilsson and Lillemor Funke and Bo N Nilsson and Kristina Nilsson Ekdahl},
  booktitle={Upsala journal of medical sciences},
  year={2011}
}
INTRODUCTION The complement system is an essential part of the immune system of vertebrates. The central event of the complement activation cascade is the sequential proteolytic activation of C3, which is associated with profound alterations in the molecule's structure and conformation and is responsible for triggering most of the biological effects of complement. MATERIAL AND METHODS Here, we have studied the conformation of C3 fragments deposited onto an IgG-coated surface from human serum… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Deposition of C 3 b / iC 3 b leads to the concealment of antigens , immunoglobulins and bound C 1 q in complement - activating immune complexes

  • NilssonUR
  • Mol Immunol
  • 2001

Similar Papers

Loading similar papers…