Two-component regulatory system involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus.

@article{Lelie1997TwocomponentRS,
  title={Two-component regulatory system involved in transcriptional control of heavy-metal homoeostasis in Alcaligenes eutrophus.},
  author={Daniel van der Lelie and T Schwuchow and Uta Schwidetzky and Stefan Wuertz and Wilfried Baeyens and Max Mergeay and Dietrich H Nies},
  journal={Molecular microbiology},
  year={1997},
  volume={23 3},
  pages={493-503}
}
The czc determinant, which mediates resistance to Co2+, Zn2+ and Cd2+ in Alcaligenes eutrophus CH34 by cation efflux, is regulated by a two-component regulatory system composed of the sensor histidine kinase CzcS and the response activator CzcR (in addition to other components previously described). Regulatory genes are arranged in an upstream regulatory region (URR) and a downstream regulatory region (DRR). Transcription of czcCBA and of the URR was regulated by heavy-metal cations. DNA… CONTINUE READING

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