Two complementation groups account for most cases of inherited MHC class II deficiency.

@article{LisowskaGrospierre1994TwoCG,
  title={Two complementation groups account for most cases of inherited MHC class II deficiency.},
  author={Barbara Lisowska-Grospierre and M. C. Fondaneche and Marie Pierre Rols and Claude Griscelli and Alain Fischer},
  journal={Human molecular genetics},
  year={1994},
  volume={3 6},
  pages={
          953-8
        }
}
MHC class II immuno-deficiency is a rare autosomal recessive disease due to a defect in transacting genes, which control the expression of the entire family of MHC alpha and beta class II genes. Previous analyses classified cells from eight MHC class II-deficient patients and four experimental mutant cell lines into four complementation groups, pointing to the existence of a large number of regulatory genes. We conducted fusion experiments with cell lines from two-thirds of all known patients… CONTINUE READING
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