Two-compartment tumor metabolism : autophagy in the tumor microenvironment and oxidative mitochondrial metabolism ( OXPHOS ) in cancer cells

@inproceedings{Salem2012TwocompartmentTM,
  title={Two-compartment tumor metabolism : autophagy in the tumor microenvironment and oxidative mitochondrial metabolism ( OXPHOS ) in cancer cells},
  author={Ahmed F. Salem and Diana Whitaker-Menezes and Zhao Lin and Ubaldo e. Martinez-outschoorn and Mazhar Al-Zoubi and Anthony Howell and Richard G. Pestell and Federica Sotgia and Michael Phillip Lisanti},
  year={2012}
}
Autophagy is a conserved process of “self-eating” of both proteins and cell organelles. This process is triggered as an adaptation to cellular stress, which is caused by several factors, such as starvation, hypoxia, oxidative stress and DNA damage. Autophagy is initiated when the autophagosome, a double-membrane vesicle, engulfs cytoplasmic organelles. Autophagosomes fuse with lysosomes, which digests the vesicle’s contents. If excessive numbers of autophagic vacuoles accumulate, programmed… CONTINUE READING
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