Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population.

@article{Hu2011TwoCS,
  title={Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population.},
  author={Yi Hu and Chun-mei Liu and Lu Qi and T He and Liu Shi-Guo and Chan-juan Hao and Yi Cui and Ning Zhang and Hong-fei Xia and Xu Tong Ma},
  journal={RNA biology},
  year={2011},
  volume={8 5},
  pages={861-72}
}
Although there are plenty of evidence that single-nucleotide polymorphisms (SNPs) that fall within coding sequences of genes are involved in recurrent pregnancy loss (RPL), it is still unknown whether the polymorphisms in microRNAs (miRNAs) are related with RPL. In this study, we established this kind of association by confirming significant differences in genotype distribution of rs41275794 (P= 0.0005) and rs12976445 (P= 0.001) within the pri-miR-125a in 217 Han Chinese patients of RPL… CONTINUE READING

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