Two classes of plant-like vacuolar-type H(+)-pyrophosphatases in malaria parasites.

@article{Mcintosh2001TwoCO,
  title={Two classes of plant-like vacuolar-type H(+)-pyrophosphatases in malaria parasites.},
  author={Michael T. Mcintosh and Yolanda M. Drozdowicz and K Laroiya and Philip A. Rea and Akhil B. Vaidya},
  journal={Molecular and biochemical parasitology},
  year={2001},
  volume={114 2},
  pages={183-95}
}
In plants, cytosolic inorganic pyrophosphate (PP(i)) is hydrolyzed by energy-conserving vacuolar-type H(+)-pyrophosphatases (V-PPases) that harness the free energy of PP(i) hydrolysis to establish transmembrane H(+) gradients. Here we describe the identification and cloning of two genes, PfVP1 and PfVP2, from the malaria parasite Plasmodium falciparum. Inferred to encode type I (K(+)-dependent) and type II (K(+)-independent) V-PPases, respectively, PfVP1 and PfVP2 appeared more sequence… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…