Two classes of outer hair cells along the tonotopic axis of the cochlea.

@article{Engel2006TwoCO,
  title={Two classes of outer hair cells along the tonotopic axis of the cochlea.},
  author={Jutta Engel and Claudia Braig and Lukas Ruettiger and Stephanie Kuhn and Ulrike Zimmermann and Nikolaus Blin and Matthias Sausbier and Hubert Kalbacher and Stefan Muenkner and Karin Rohbock and Peter J. van Ruth and Harald Winter and Marlies Knipper},
  journal={Neuroscience},
  year={2006},
  volume={143 3},
  pages={837-49}
}
The molecular basis of high versus low frequency hearing loss and the differences in the sensitivity of outer hair cells depending on their cochlear localization are currently not understood. Here we demonstrate the existence of two different outer hair cell phenotypes along the cochlear axis. Outer hair cells in low frequency regions exhibit early sensitivity for loss of Ca(v)1.3 (alpha1 subunit 1.3 forming the class D L-type voltage-gated Ca(2+) channel), while high frequency regions display… CONTINUE READING
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