Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins.

@article{Yasugi1997TwoCO,
  title={Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins.},
  author={Toshiharu Yasugi and M D Rubio Vidal and Hiroyuki Sakai and Peter M Howley and John D. Benson},
  journal={Journal of virology},
  year={1997},
  volume={71 8},
  pages={5942-51}
}
Random mutagenesis of human papillomavirus type 16 (HPV16) E1 was used to generate E1 missense mutants defective for interaction with either hUBC9 or 16E1-BP, two cDNAs encoding proteins that have been identified by their ability to interact with HPV16 E1 in two-hybrid assays. hUBC9, the human counterpart of Saccharomyces cerevisiae UBC9, is a ubiquitin-conjugating enzyme known to be involved in cell cycle progression. 16E1-BP encodes a protein of no known function but does contain an ATPase… CONTINUE READING

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Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitinconjugating enzyme

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