Two cases showing clonal progression with full evolution from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome to myelodysplastic syndromes and leukemia.

@article{Ishihara2000TwoCS,
  title={Two cases showing clonal progression with full evolution from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome to myelodysplastic syndromes and leukemia.},
  author={Shunji Ishihara and Hideki Nakakuma and Tatsuya Kawaguchi and Shoichi Nagakura and Kentaro Horikawa and Michihiro Hidaka and Norio Asou and Hiroaki Mitsuya},
  journal={International journal of hematology},
  year={2000},
  volume={72 2},
  pages={206-9}
}
We report 2 paroxysmal nocturnal hemoglobinuria (PNH) patients who were initially diagnosed with aplastic anemia and sequentially developed PNH, myelodysplastic syndromes (MDS), and leukemia. Flow cytometry and cytogenetic analysis showed the initial appearance and expansion of PNH clones, gradual replacement of PNH clones by MDS clones with monosomy 7, and then expansion of MDS clones or their subclones with additional chromosomal abnormalities. In relation to these developments, expression… CONTINUE READING