Two cases of intoxication with new synthetic opioid, U-47700

@article{Domanski2017TwoCO,
  title={Two cases of intoxication with new synthetic opioid, U-47700},
  author={Kristina Domanski and Kurt C. Kleinschmidt and J M Schulte and Steven W Fleming and Clarence C. Frazee and Annelle Menendez and Kh. Tavakoli},
  journal={Clinical Toxicology},
  year={2017},
  volume={55},
  pages={46 - 50}
}
BACKGROUND Novel substances often referred to as "designer drugs" have emerged as drugs of abuse, and recognition of these is difficult as routine blood and urine screening tests do not detect these agents. [] Key MethodCASE DETAILS A 26-year-old man and 24-year-old woman insufflated a substance they believed to be "synthetic cocaine." The man was found down with cyanosis and agonal respirations. He was intubated and taken to hospital where he recovered well with supportive care. The woman presented with…
Another fatal case related to the recreational abuse of U-47700
TLDR
A non-targeted liquid chromatography/mass spectrometry (LC/MS)-based screening approach of urine and cerebrospinal fluid samples after intravenous injection of trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide (U-47700) shows that the powder had a relatively high purity and was adulterated to a low degree.
Postmortem concentration distribution in fatal cases involving the synthetic opioid U-47700
TLDR
The data concerning U-47700 concentration distribution in postmortem specimens collected after two lethal intoxications showed femoral blood concentrations were lower than the urine/heart blood concentrations and can be defined as high when compared with toxic morphine levels, well known that the interpretation of postmortem drug concentration is a big challenge.
Analysis of U-47700, a Novel Synthetic Opioid, in Human Urine by LC-MS-MS and LC-QToF.
TLDR
Findings suggest that U-47700 drug may cause significant morbidity and mortality within the United States as an emerging drug threat.
Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: The First Reported Case in the Czech Republic
TLDR
A case of near‐fatal U‐47700 intoxication of a man found unconscious (with drug powder residues) is reported, after 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged.
A Fatality Related to the Synthetic Opioid U-47700: Postmortem Concentration Distribution.
TLDR
An evaluation of the distribution of postmortem concentrations of 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) in a fatality attributed principally to the drug is presented.
New synthetic opioid cyclopropylfentanyl together with other novel synthetic opioids in respiratory insufficient comatose patients detected by toxicological analysis
TLDR
In cases of intoxication without a medical history, the detailed toxicological analysis may reveal new psychoactive substances which are not detected by standard toxicological screening approaches.
U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market
TLDR
The evidence demonstrates that U-47700 is a potent μ-opioid receptor agonist, which poses a serious risk for overdosing and death, however, most analogs of U- 47700 appear to be less potent and have been detected infrequently in forensic specimens.
Novel synthetic opioids – toxicological aspects and analysis
TLDR
Clinicians dealing with fentanyl intoxication cases should consider that it could, in fact, be a fentanyl analogue, and recommend to include synthetic opioids in the routine toxicological screening procedures, including analysis in alternative matrices, if available, to investigate poly-drug use and possible tolerance to opioids.
...
...

References

SHOWING 1-10 OF 19 REFERENCES
AH-7921: the list of new psychoactive opioids is expanded
TLDR
AH-7921 is a current public health risk, and better international collaboration, effective legislation and continuous community alertness are needed to tackle this current growing problem.
Synthetic Cathinones: A New Public Health Problem
TLDR
The major clinical effects of synthetic cathinones are reviewed to highlight their impact on public health.
The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis.
TLDR
The search for synthetic opioids as alternatives to opium-based derivatives has provided an important impulse to drug development around the globe, but the exploration of these important discoveries has also been increasingly mined by largescale producers of these materials, which are then offered for sale.
New designer drugs (synthetic cannabinoids and synthetic cathinones): review of literature.
TLDR
The absence of legal risks, the ease of obtaining these drugs, the moderate cost, and the availability via the Internet are the main features that attract users, but the number of intoxicated people presenting with emergencies is increasing.
U-50,488 and the к receptor: A personalized account covering the period 1973 to 1990
TLDR
U-50,488 provided a succinct template for structural modifications and they are described for the period up to 1990 and a description of the structural classes of K agonists is provided including a summary of K recognition sites based on known agonists.
Increases in Drug and Opioid Overdose Deaths—United States, 2000–2014
TLDR
Findings indicate that the opioid overdose epidemic is worsening and there is a need for continued action to prevent opioid abuse, dependence, and death, improve treatment capacity for opioid use disorders, and reduce the supply of illicit opioids, particularly heroin and illicit fentanyl.
Factors affecting binding of trans-N-[2-(methylamino)cyclohexyl]benzamides at the primary morphine receptor.
In this paper, we describe the synthesis of a series of trans-N-[2-(methylamino)cyclohexyl]benzamides possessing morphine-like pharmacological properties. The affinity of the compounds for the
U-50,488 and the r receptor: a personalized account covering the period
  • Jucker E, editor. Progress in drug research,
  • 1973
...
...