Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B.

Abstract

BACKGROUND Entecavir (ETV) is a potent nucleoside analogue against hepatitis B virus (HBV), and emergence of drug resistance is rare in nucleoside-naive patients because development of ETV resistance (ETVr) requires at least three amino acid substitutions in HBV reverse transcriptase. We observed two cases of genotypic ETVr with viral rebound and… (More)
DOI: 10.1007/s12072-008-9108-8

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