Two cases of asymptomatic HBV “vaccine breakthrough” infection detected in blood donors screened for HBV DNA

@article{Seed2012TwoCO,
  title={Two cases of asymptomatic HBV “vaccine breakthrough” infection detected in blood donors screened for HBV DNA},
  author={Clive R. Seed and Ngaire T Jones and Anne M Pickworth and Wendy J. Graham},
  journal={Medical Journal of Australia},
  year={2012},
  volume={196}
}
A 35-year-old male first-time blood donor who donated in June 2011 tested positive for HBV (hepatitis B virus) DNA (Box). DNA sequencing analysis identified HBV genotype E. The only other HBV marker present was anti-HBs (antibodies to HBV surface antigen), attributable to a full course of vaccination in 2003–2004. A followup interview identified heterosexual contact with a new partner as the likely source of infection. HBsAg (HBV surface antigen) remained undetectable throughout the 90-day… 
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References

SHOWING 1-10 OF 11 REFERENCES
Nucleic acid testing to detect HBV infection in blood donors.
TLDR
Triplex nucleic acid testing detected potentially infectious HBV, along with HIV and HCV, during the window period before seroconversion, and HBV vaccination appeared to be protective, with a breakthrough subclinical infection occurring with non-A2 HBV subgenotypes and causing clinically inconsequential outcomes.
Breakthrough of hepatitis B virus escape mutants after vaccination and virus reactivation.
  • W. Gerlich
  • Biology, Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2006
Antibody Levels and Protection after Hepatitis B Vaccination: Results of a 15-Year Follow-up
TLDR
Data is reported on the persistence of antibodies to hepatitis B surface antigen (anti-HBs), incidence of HBV infection, and the genetic characteristics of the HBV isolates in persons with breakthrough infections 15 years after initial vaccination of this cohort.
Occult hepatitis B virus infection in Thai blood donors
TLDR
An evaluation by the National Blood Center, the Thai Red Cross Society, of two commercial multiplex nucleic acid tests for screening Thai blood donors for hepatitis B virus (HBV), hepatitis C virus, and human immunodeficiency virus Type 1 identified 175 HBV NAT–reactive/hepatitis B surface antigen (HBsAg)‐negative donors.
PRISM hepatitis B surface antigen detection of hepatits B virus minipool nucleic acid testing yield samples
TLDR
In this study, eight samples identified as yield samples with MP HBV NAT were tested using the PRISM test and showed no differences in the results between the Abbott PRISM and MP tests.
Transfusion - transmission of hepatitis B virus ( HBV ) from a NAT - negative occult hepatitis B virus carrier
  • Vox Sang
  • 2011
...
1
2
...