Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.

@article{Amengual2013TwoCO,
  title={Two carotenoid oxygenases contribute to mammalian provitamin A metabolism.},
  author={Jaume Amengual and Made Airanthi K. Widjaja-Adhi and Susana Rodriguez-Santiago and Susanne Hessel and Marcin Golczak and Krzysztof Palczewski and Johannes von Lintig},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 47},
  pages={
          34081-96
        }
}
Mammalian genomes encode two provitamin A-converting enzymes as follows: the β-carotene-15,15'-oxygenase (BCO1) and the β-carotene-9',10'-oxygenase (BCO2). Symmetric cleavage by BCO1 yields retinoids (β-15'-apocarotenoids, C20), whereas eccentric cleavage by BCO2 produces long-chain (>C20) apocarotenoids. Here, we used genetic and biochemical approaches to… CONTINUE READING