Two brain sites for cannabinoid reward.

  title={Two brain sites for cannabinoid reward.},
  author={Abraham Zangen and Marcello Solinas and Satoshi Ikemoto and Steven R. Goldberg and Roy Wise},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={26 18},
The recent findings that Delta9tetrahydrocannabinol (Delta9THC), the active agent in marijuana and hashish, (1) is self-administered intravenously, (2) potentiates the rewarding effects of electrical brain stimulation, and (3) can establish conditioned place preferences in laboratory animals, suggest that these drugs activate biologically primitive brain reward mechanisms. Here, we identify two chemical trigger zones for stimulant and rewarding actions of Delta9THC. Microinjections of Delta9THC… CONTINUE READING
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The effects of delta 9tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study

  • JM Ng Cheong Ton, GA Gerhardt, +4 authors EL Gardner
  • Brain Res
  • 1988
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