Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.

  title={Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.},
  author={David R. Owen and Owain W Howell and Sac-Pham Tang and Lisa Wells and Idriss Bennacef and Mats Bergstrom and Roger N. Gunn and Eugenii A. Rabiner and Martin R Wilkins and Richard G Reynolds and Paul M. Matthews and Christine A. Parker},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={30 9},
[(11)C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not been reported for [(11)C]PK11195, another TSPO radioligand. We measured the specific binding signals with [(3)H]PK11195 and [(3)H]PBR28 in brain tissue from 22 donors. Overall, 23% of the samples did not generate a visually detectable specific autoradiographic signal with [(3)H]PBR28, although all samples showed [(3… CONTINUE READING

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