Two benzene metabolites, catechol and hydroquinone, produce a synergistic induction of micronuclei and toxicity in cultured human lymphocytes.

@article{Robertson1991TwoBM,
  title={Two benzene metabolites, catechol and hydroquinone, produce a synergistic induction of micronuclei and toxicity in cultured human lymphocytes.},
  author={Moire L. Robertson and David A. Eastmond and Martyn T. Smith},
  journal={Mutation research},
  year={1991},
  volume={249 1},
  pages={
          201-9
        }
}
A mixture of two benzene metabolites, hydroquinone and catechol, produces a striking synergistic genotoxic response in cultured human lymphocytes. This was demonstrated using an anti-kinetochore antibody modification of the micronucleus assay. Treatment with hydroquinone alone or in combination with phenol produced a 3-fold increase in micronucleated cells over background. Treatment with catechol or phenol alone and in combination produced only minor increases in the number of micronucleated… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 33 CITATIONS

Carcinogenic Effects of Benzene : An Update

  • 1998
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic.

  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2010
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Studies on the mechanism of benzene toxicity.

  • Environmental health perspectives
  • 1989
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

An interaction of benzene metabolites reproduces the myelotoxicity produced with benzene exposure, Toxicol

D. A. Eastmond, M. T. Smith, R.D
  • Irons
  • 1987
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Allelotype of colorectal carcinomas

J. W. Yager, D. A. Eastmond, M. L. Robertson, M. T. Smith
  • 1989

Introduction: Occam's razor is dull, Environ

B. D. Goldstein
  • Health Perspect.,
  • 1989
VIEW 2 EXCERPTS