Two axes in platelet-derived growth factor signaling: tyrosine phosphorylation and reactive oxygen species

@article{Kang2007TwoAI,
  title={Two axes in platelet-derived growth factor signaling: tyrosine phosphorylation and reactive oxygen species},
  author={Sung Wook Kang},
  journal={Cellular and Molecular Life Sciences},
  year={2007},
  volume={64},
  pages={533-541}
}
The tyrosine phosphorylation cascade is a hallmark of platelet-derived growth factor (PDGF)- induced signal transduction. The amplitude and propagation of the tyrosine phosphorylation signal relies on the balance between tyrosine kinase and tyrosine phosphatase. The tyrosine kinase is latent in the absence of stimulation, whereas the tyrosine phosphatase is highly and constitutively active. Therefore, the kinase activation should be accompanied by temporal and spatial inactivation of tyrosine… CONTINUE READING

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