Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons

@article{Snow2004TwoAI,
  title={Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons},
  author={Joshua J. Snow and Guangshuo Ou and Amy L. Gunnarson and M. Regina S. Walker and H. Mimi Zhou and Ingrid Brust-Mascher and Jonathan M. Scholey},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={1109-1113}
}
Cilia have diverse roles in motility and sensory reception and their dysfunction contributes to cilia-related diseases. Assembly and maintenance of cilia depends on the intraflagellar transport (IFT) of axoneme, membrane, matrix and signalling proteins to appropriate destinations within the organelle. In the current model, these diverse cargo proteins bind to multiple sites on macromolecular IFT particles, which are moved by a single anterograde IFT motor, kinesin-II, from the ciliary base to… CONTINUE READING
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