Two amino acid substitutions in the SIV Nef protein mediate associations with distinct cellular kinases.

@article{Barber2000TwoAA,
  title={Two amino acid substitutions in the SIV Nef protein mediate associations with distinct cellular kinases.},
  author={Sheila A. Barber and Maureen F. Maughan and J. W. Roos and Janice E. Clements},
  journal={Virology},
  year={2000},
  volume={276 2},
  pages={329-38}
}
A functional Nef protein is crucial in vivo for viral replication leading to pathogenesis in SIV-infected macaques. Moreover, a full-length Nef protein is required for optimal virus replication in primary cells, and both HIV and SIV Nef proteins enhance virion infectivity. Enhanced infectivity may result in part from the ability of Nef to incorporate cellular kinases into virions. In two previous reports, we compared in vitro kinase profiles of SIV recombinant clones that express nef genes… CONTINUE READING