Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase.

Abstract

Guanylyl cyclases (GCs) and adenylyl cyclases (ACs) have fundamental roles in a wide range of cellular processes. Whereas GCs use GTP as a substrate to form cGMP, ACs catalyze the analogous conversion of ATP to cAMP. Previously, a model based on the structure of adenylate cyclase was used to predict the structure of the nucleotide-binding pocket of a… (More)

Topics

5 Figures and Tables

Cite this paper

@article{Tucker1998TwoAA, title={Two amino acid substitutions convert a guanylyl cyclase, RetGC-1, into an adenylyl cyclase.}, author={Cindy Tucker and Joyce Harts Hurley and T. R. Miller and Jeremy Hurley}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1998}, volume={95 11}, pages={5993-7} }