Two alternative translation mechanisms are responsible for the expression of the HCV ARFP/F/core+1 coding open reading frame.

@article{Vassilaki2003TwoAT,
  title={Two alternative translation mechanisms are responsible for the expression of the HCV ARFP/F/core+1 coding open reading frame.},
  author={Niki Vassilaki and Penelope Mavromara},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 42},
  pages={40503-13}
}
HCV-1 produces a novel protein, known as ARFP, F, or core+1. This protein is encoded by an open reading frame (ORF) that overlaps the core gene in the +1 frame (core+1 ORF). In vitro this protein is produced by a ribosomal frameshift mechanism. However, similar studies failed to detect the ARFP/F/core+1 protein in the HCV-1a (H) isolate. To clarify this issue and to elucidate the functions of this protein, we examined the expression of the core+1 ORF by the HCV-1 and HCV-1a (H) isolates in vivo… CONTINUE READING
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Expression of the HCV Core 1 ORF 40513 by gest on N ovem er 18

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