Two alpha(1-3) glucan synthases with different functions in Aspergillus fumigatus.

@article{Beauvais2005TwoAG,
  title={Two alpha(1-3) glucan synthases with different functions in Aspergillus fumigatus.},
  author={Anne Beauvais and Danielle Maubon and Sohyeon Park and Willy Morelle and Myriam Tanguy and Michel Ren{\'e} Huerre and David Scott Perlin and Jean Paul Latg{\'e}},
  journal={Applied and environmental microbiology},
  year={2005},
  volume={71 3},
  pages={
          1531-8
        }
}
Alpha(1-3) glucan is a main component of the Aspergillus fumigatus cell wall. In spite of its importance, synthesis of this amorphous polymer has not been investigated to date. Two genes in A. fumigatus, AGS1 and AGS2, are highly homologous to the AGS genes of Schizosaccharomyces pombe, which encode putative alpha(1-3) glucan synthases. The predicted Ags proteins of A. fumigatus have an estimated molecular mass of 270 kDa. AGS1 and AGS2 were disrupted in A. fumigatus. Both Deltaags mutants have… CONTINUE READING

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