Two-allergen model reveals complex relationship between IgE crosslinking and degranulation.


Allergy is an immune response to complex mixtures of multiple allergens, yet current models use a single synthetic allergen. Multiple allergens were modeled using two well-defined tetravalent allergens, each specific for a distinct IgE, thus enabling a systematic approach to evaluate the effect of each allergen and percentage of allergen-specific IgE on… (More)
DOI: 10.1016/j.chembiol.2014.08.019


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