Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity

@article{Hudson1993TwoAR,
  title={Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity},
  author={Keith R. Hudson and Helen Robinson and John D Fraser},
  journal={The Journal of Experimental Medicine},
  year={1993},
  volume={177},
  pages={175 - 184}
}
The T cell receptor (TCR) V beta-determining region of two bacterial superantigens, staphylococcal enterotoxin A (SEA) and SEE, has been mapped to the COOH-terminal region of SEA and SEE using a panel of recombinant SEA/SEE hybrids. Total TCR V beta mRNA enrichment in human peripheral blood T cell cultures was determined by a novel single-tube amplification technique using a redundant V beta-specific primer. SEA routinely enriched mRNA coding for hV beta 1.1, 5.3, 6.3, 6.4, 6.9, 7.3, 7.4, and 9… CONTINUE READING

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